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The efficacy population in trial B constituted members who gained all drug doses and had cold pressor efficacy information from all three segments. A sensitivity Investigation was executed by conducting the analyses for the ITT, for every-protocol, and efficacy populations as defined. All results presented are for the ITT inhabitants; Until normally specified, final results from your for every-protocol and efficacy populace analyses supported those with the ITT populace. The security population bundled all sufferers who obtained research drug. All safety analyses were being done on the safety populace.

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